I've gone to using one list as much as possible, but that's mostly about tightening up my own gameplay. One list, play the everliving crap out of it. With my Nomads, when I do take a different list, I usually keep a consistent core and vary around the edges. Partially this is for fluff purposes. I'm a big fan of my Interventor LT, the Specula Killa. I always start with my Interventor LT, a Clockmaker with two Zondbots, at least two infiltrating specialists (Zero hacker or Moran FO), and 2-6 Chain Rifle Morlocks. I usually include two attack REMs (Tsyklon, Luno, Reaktion, or Puppet Troupe). The rest is up for grabs. Maybe a Tomcat or a Hellcat, Mary Problems, a Hollow Man, an Interventor KHD, Zoe and Pi-Well, EVO bot, or Salyut and/or Transducer cheerleaders. Right now, I tend to play towards the midfield. Infiltrate and do objectives/lay mines/set koalas/suppressive fire, cover attack REM advance with smoke, establish a strong repeater presence. Once I feel like I've got that working well in most missions against most opponents (I don't need to win, just get handy at dealing with most situations), I'll probably see about how swapping around some optional components can tighten up my game. Introduce some long range pieces, backfield harassment, etc.