Having said all that, one of my tables is set up to have tall buildings surrounding a plaza in the middle, but its mitigated by the tallest buildings having minimal cover and the plaza being full of cover, as well as planters with tons of foliage, so its actually safer to move around at ground level than it is to be attacking from rooftop to rooftop.
Sure, if you have any skill with 3d modeling (or a friend with skill), and $600+ for a 3d Printer. I bought that terrain about $100 at a time over significant time, and at a time when the 3d Printer I needed due to resolution limits was $1000.
We generally always use asymmetry in our tables. But we try for the asymmetry to be evident left to right instead of by deployment zone if that makes sense. i.e. slummy nest of buildings will be on my left (opponenets right) and open car park will be vice versa. This is opposed to me deploying in an open carpark and opponent gets the slums if that makes sense. Beyond that its just making ensuring that each deployment edge has a sniper roost (optional) and 1-2 items of total cover in reach of the first turn if not deployment.